/tools/antibody-affinity-engineering
antibody-affinity-engineering
izgys/antibody-affinity-engineering
2 stars0 forksAdded February 4, 2026
summary
This repository provides a computational pipeline for enhancing antibody-antigen binding affinity using AI-based mutation generation and structural modeling. It employs tools like ProteinMPNN and FoldX to predict binding affinities and evaluate antibody variants, making it a valuable resource for antibody engineering.
description
A computational pipeline for improving antibody-antigen binding affinity through CDR-focused mutations, using AI-based inverse folding (ProteinMPNN), structural modeling (IgFold, AlphaFold-Multimer), and binding affinity prediction with FoldX. Designed for antibody engineering and rational biologic design.
topics
antibody-designmachine-learning
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