/tools/esm2-rl-designer

esm2-rl-designer

varshhhy7/esm2-rl-designer

16 stars0 forksJupyter NotebookAdded February 8, 2026
summary

ESM2-RL Designer is a framework for controllable protein design that fine-tunes a pretrained protein language model using reinforcement learning. It aims to generate protein sequences with specific properties such as stability and diversity through a multi-objective reward system.

description

Research framework for fine-tuning a pretrained protein language model (ESM-2) using reinforcement learning. Uses LoRA and multi-objective rewards to steer protein generation toward stability, diversity, and constraint satisfaction, with experiments designed to study trade-offs under different reward designs.

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